2018 US Open Tennis Odds: Serena Williams Favored to Win Womens Title There are exceptions for the best athletes in many sports, and womens tennis is one of them. That would help explain why Serena Williams is listed as the+500 favorite on the 2018 U. S. Open tennis odds at sportsbooks monitored by OddsShark, despite being the 17th seed in the womens draw at the Billie Jean King National Tennis Center in New York. Kerber is the fourth seed in this years U. S. Open and the+700 co-second choice to win it along with top seed Simona Halep, who has never made it to the final of this tournament. Other top contenders in the mix on the WTA tennis odds to win the womens singles title include defending champion and third-seeded Sloane Stephens , 12th-seeded Garbine Muguruza , second-seeded Caroline Wozniacki and seventh-seeded Elina Svitolina . Three more women to watch on the odds to win the U. S. Open are fifth-seeded Petra Kvitova , eighth-seeded Karolina Pliskova and sixth-seeded Caroline Garcia .