Los Angeles Rams vs. San Francisco 49ers Odds, Analysis, NFL Betting Pick The Rams look like the best team in the NFC at the moment, while the 49ers are struggling without their starting quarterback. Whos the smart money pick for Sunday afternoons NFC West bout in Santa Clara? NFL point spread: The Rams opened as 11-point favorites; the total was 53.5 early in the week, according to sportsbooks monitored by OddsShark. NFL betting pick, via OddsShark computer:32.5-21.0 Rams The 49ers are coming off a valiant effort Monday night, although it resulted in a 33-30 loss to the Packers in Green Bay. San Francisco actually drove the opening possession of the game 75 yards to a touchdown, fell down to the Packers 17-7 then used a 23-6 run spanning the halves to take a 30-23 lead late into the fourth quarter.