A rare genetic mutation revealed at the Amish community in the United States explains their longevity and, according to scientists, opens the way for the treatment of degeneration caused by aging.
"It's the first human genetic mutation that has been proven to have many impacts on biological changes caused by aging," said Professor Douglas Von, president of the Medical School at the Northwest University in Chicago.
It has been shown that 43 people have a "serpin one" mutation, which greatly reduces the production of PAI-1 proteins, and they have better health and live at least 10 years longer than people who do not have this mutation. The expected life expectancy in the US is 78.8 years.
The international scientific team found that Amish's "metabolic profile" is healthier and that they are significantly less prone to diabetes and cardiovascular disease. Also, it was discovered that the "telomers" of their antibodies were at least 10 percent longer. "Telomers" are a part of the DNA that is at the end of each chromosome for protection and which is reduced by any cell division, contributing to aging.
Amish are closed, very strictly disciplined Christian community originating in Switzerland. They grouped emigrated to America in the 18th century, where it is estimated that there are 250,000, mostly in the United States. They live simply, isolate themselves from others, wear very modestly, mostly produce food using ancient methods, and they are considered ecological and healthy, and reject modern technology and devices.